Chenxi Liu


Research Interests

Howdy! My name is Chenxi (He/Him). My research centers around several core questions: 1. How does spatial structure shape the evolution of bacteriophage? 2. Can we use a model to predict the outcome of bacteriophage evolution to inform phage therapy? 3. Reversibility of bacteriophage virulence phenotype and its underlying genetic mechanisms.


1. Wendt, G., Zhao, L., Chen, R., Liu, C., O’Donoghue, A. J., Caffrey, C. R., Reese, M. L., & Collins, J. J., 3rd (2020). A single-cell RNA-seq atlas of Schistosoma mansoni identifies a key regulator of blood feeding. Science (New York, N.Y.), 369(6511), 1644–1649.

2. Keller, L., Canuto, K. M., Liu, C., Suzuki, B. M., Almaliti, J., Sikandar, A., Naman, C. B., Glukhov, E., Luo, D., Duggan, B. M., Luesch, H., Koehnke, J., O’Donoghue, A. J., & Gerwick, W. H. (2020). Tutuilamides A-C: Vinyl-Chloride-Containing Cyclodepsipeptides from Marine Cyanobacteria with Potent Elastase Inhibitory Properties. ACS chemical biology, 15(3), 751–757.

3. Padalino, G., El-Sakkary, N., Liu, L. J., Liu, C., Harte, D., Barnes, R. E., Sayers, E., Forde-Thomas, J., Whiteland, H., Bassetto, M., Ferla, S., Johnson, G., Jones, A. T., Caffrey, C. R., Chalmers, I., Brancale, A., & Hoffmann, K. F. (2021). Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation. European journal of medicinal chemistry, 226, 113823.

4. Reher, R., Aron, A. T., Fajtová, P., Stincone, P., Wagner, B., Pérez-Lorente, A. I., Liu, C., Shalom, I. Y. B., Bittremieux, W., Wang, M., Jeong, K., Matos-Hernandez, M. L., Alexander, K. L., Caro-Diaz, E. J., Naman, C. B., Scanlan, J. H. W., Hochban, P. M. M., Diederich, W. E., Molina-Santiago, C., Romero, D., … Petras, D. (2022). Native metabolomics identifies the rivulariapeptolide family of protease inhibitors. Nature communications, 13(1), 4619.

Rewards and Honors

Hoag Award (2023)

Walker Family Award (2023)