Adventures in Sterile Technique
My research concerns how organisms adapt to different gradients of selective pressure. I’m investigating whether populations that experience a gradual unidirectional shift in their environment are able to access different mutational pathways that allow them access to higher fitness peaks in the final environment than populations that experience a more rapid shift to that final environment. To test this, we’ve evolved E. coli by serial transfer in treatment groups exposed to different gradients of antibiotic and analyzed the fitness and mutations of the surviving population. I have also engineered different combinations of mutations found in the surviving populations and introduced them into a common genetic background. I am currently testing the fitness of these engineered mutants across a gradient of antibiotic concentrations to determine which mutational pathways are accessible to our populations over the course of their evolution. I have a BS in Ecology and Evolution from UW.
- haleyl [snail] uw [period] edu -> mailto:haleyl [snail] uw [period] edu
- 410D Kincaid Hall
- Mailing Address
Haley Lindsey c/o Kerr Lab Department of Biology University of Washington Box 351800 Seattle, WA 98195 USA